INTRANUCLEAR FIBRILLAR BODIES IN ACTINOMYCIN D-TREATED OOCYTES

Intranuclear Fibrillar Bodies in Actinomycin D-treated Oocytes

Earlier investigations have shown that actinomycin D, which inhibits DNA-dependent RNA synthesis (Reich et al., 1961) by binding to DNA (Kirk, 1960), has a profound effect on the nuclear structure of cells. Some of the most striking consequences are visible in the nucleoli which exhibit both a decrease in size and a variety of fine structural changes (Journey and Goldstein, 1961; Reynolds et al...

An intranuclear fibrillar lattice in neurons.

A new intranuclear structure has been demonstrated in neurons of rat and mouse brain, and studied using conventional electron microscopy and electron stereoscopy techniques. The structure has a crystalline appearance and a variety of profiles was seen in the sections, some showing curvature and one showing ellipticity. The basic component consisted of planes of parallel fibrils; layers of these...

Intranuclear paracrystalline fibrillar arrays in human glioma cells.

Multiple myeloma with numerous intranuclear Russell bodies.

Correspondence: A. Martín-Noya, M.D., Servicio de Hematología, Hospital Universitario Virgen del Rocío, Avda. Manuel Siurot s/n1, 41013 Seville, Spain. Phone: international +34-95-4248122 – Fax: international +34-954248124 – E-mail: [email protected] A71-year-old woman was admitted to hospital because of repeated episodes of epistaxis and an eight month history of fatigue and weight loss. On ph...

Dcp1-bodies in mouse oocytes.

Processing bodies (P-bodies) are cytoplasmic granules involved in the storage and degradation of mRNAs. In somatic cells, their formation involves miRNA-mediated mRNA silencing. Many P-body protein components are also found in germ cell granules, such as in mammalian spermatocytes. In fully grown mammalian oocytes, where changes in gene expression depend entirely on translational control, RNA g...